Loss of GBP5 function in a knockout mouse model results in impaired host defense and inflammatory response as GBP5 facilitates nucleotide-binding domain and leucine-rich repeat containing gene family, pyrin domain containing 3 (NLRP3)-mediated inflammasome assembly.24 Mice lacking functional GBP5 had significantly reduced neutrophil recruitment in response to peritonitis. The gene discussed is NLRP3; the disease is peritonitis.