From a long list of candidate genes, this approach identified one novel variant inCHD1 shared by three affected second cousins in a single multiplex family.CHD1 is a strong candidate gene because mutations in this gene can cause both gastric cancer and orofacial clefts, and several studies have shown evidence of association or excess of rare variants in this gene44–47. The gene discussed is CHD1; the disease is orofacial cleft.