ERBB2 and metastatic neoplasm: For patients with HER2-negative metastatic disease, the treatment approach should be tailored according to a number of prognostic factors, which include endocrine tumor status, other possible actionable targets (androgen receptor, BRCA mutation), hormonal status, prior therapies (adjuvant and metastatic), disease-free interval, comorbidities, performance status, burden of metastatic disease, patient preferences, prior toxicities, geographic accessibility to the closest cancer treatment center, and available as well as affordable cancer therapies.