PCNA and cirrhosis of liver: If we took two-fold of mean (3.12) as a value to evaluate the activity of proliferation, 6 of 30 liver cirrhosis patients with mean PCNA labeling index 5.05 ± 2.61 were considered in a high proliferative status, which was higher than that of normal liver tissue but was lower than that of HCC (10.08 ± 12.28).