MTOR and neoplasm: We also found that inhibition of both mTOR-C1 and mTOR-C2 strongly downregulated AKT activation, and the finding was consistent with the result observed in rat pheochromocytoma PC12 cell tumor model, which showed that PP242, dual mTOR complex 1 and 2 inhibitor, but not rapamycin, dramatically inhibited tumor growth, suggesting that mTORC-2 inhibition plays an important role and could disturb the mTORC1-dependent negative feedback loops [32].