It has been argued that HIV-1 enter resting naïve cells less efficiently than memory cells (Dai et al., 2009), and that VSV-pseudotyped HIV cannot fuse or establish latent infection in unstimulated, resting CD4 T cells (Agosto et al., 2009; Yu et al., 2009). The gene discussed is CD4; the disease is disease arising from reactivation of latent virus.