Studies on the distribution of latent HIV in different CD4+ T cell subsets demonstrated an about 10-fold higher infection frequency of memory versus naïve T cells (Ostrowski et al., 1999; Brenchley et al., 2004; Wightman et al., 2010; Josefsson et al., 2013a) and a major contribution of infected central memory and effector memory T cells to the total HIV-1 reservoir (Chomont et al., 2009). This evidence concerns the gene CD4 and infection.