HSPG2 and HIV infectious disease: These studies are based on resting CD4+ T cells pre-treated with the CCR7-ligand CCL19 which activates phosphatidylinositol 3-kinase (PI3K) and phospholipase C (PLC) pathways (Evans et al., 2012) increasing permissiveness of HIV infection in these cells (Saleh et al., 2007).