HIF1A and neoplasm: The same effect has been attributed to the mechanisms of tumor neoangiogenesis: Tumor cells stimulate endothelial cell migration, tube formation, and tumor angiogenesis through the induction of HIF-1 in endothelial cells (Doherty and Cleveland, 2013) due to HIF-1α stabilizing activity of released lactate (De Saedeleer et al., 2012).