Inhibition of BRD4 by both siRNA and JQ1 (or the structurally distinct, but functionally similar, chemical BRD inhibitors I-BET-151 and PFI-1) markedly reduced profibrotic mRNA expression, particularly that of Col1A1 and Acta2 (Figure 3), inhibited PDGF-mediated HSC proliferation, and blocked HSC activation during CCl4-induced liver fibrosis in mice (Ding et al., 2015). Here, COL1A1 is linked to Hepatic fibrosis.