Interestingly, knockdown of the α11 subunit in HSCs by RNA interference abolished a subset of YAP-regulated genes during HSC activation and partially reversed tissue fibrosis in a mouse model of the disease, indicating that this particular integrin represents one of likely multiple mechanosensitive upstream regulators of YAP in liver fibrosis (Martin et al., 2016). Here, IGKV3D-20 is linked to Hepatic fibrosis.