In the context of fibrosis, inhibiting BRD4 with JQ1 inhibits both lung and liver fibrosis as well as HSC activation in murine models, including reducing TGF-β-mediated Col1A1 expression and extracellular matrix remodeling (Tang et al., 2013; Ding et al., 2015). The gene discussed is COL1A1; the disease is Hepatic fibrosis.