Consistent with this notion, regulation of Hippo activation by ILK (Serrano et al., 2013), Src-FAK (Kim and Gumbiner, 2015; Li et al., 2016), and beta1 integrins (Martin et al., 2016) has been observed in the context of epithelial-mesenchyme transition, cancer, as well as tissue homeostasis in the skin (Elbediwy et al., 2016). Here, PTK2 is linked to cancer.