Of particular note, BRD4 promotes the expression of Col1A1, which encodes Type I collagen, in response to exogenous TGF-β, thereby leading to both lung and liver fibrosis (Friedman, 2008; Mederacke et al., 2013; Tang et al., 2013; Ding et al., 2015). This evidence concerns the gene COL1A1 and Hepatic fibrosis.