While YAP and BRD4 appear to regulate the expression of distinct target genes and therefore likely represent two independent pathways with unique molecular mechanisms, each is regulated by the microenvironment, and each promotes extracellular matrix stiffness and mechanotransductive signaling during liver fibrosis by serving as a coactivator for profibrotic gene transcription. This evidence concerns the gene BRD4 and Hepatic fibrosis.