Finally, the activation of antioxidants may suggest an increased fuel combustion and we have recently demonstrated in human studies that a perturbed cerebral glucose metabolism can be corrected by GLP-1 in both health and neurodegenerative disease (Lerche et al., 2008; Gejl et al., 2012, 2014, 2016). The gene discussed is GLP1R; the disease is neurodegenerative disease.