DENND1B and asthma: Genome Wide Association Studies have confirmed that variants of the DENND1B gene, located on chromosome 1q31 (Sleiman et al., 2010) and the ORMDL3 gene, located on chromosome 17q12 (Moffatt et al., 2007) underlie asthma pathogenesis in many populations (Ferreira et al., 2011; Melén et al., 2013).