CTSB and early-onset autosomal dominant Alzheimer disease: In neural tissue, excessive levels of extracellular Cathepsin B release have been associated with cell death in traumatic brain injury, brain aneurysm, and several neurologic diseases such as aminotrophic lateral sclerosis (ALS), Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease (Pišlar and Kos, 2014, Hook et al., 2015).