We note in various squamous cell type carcinomas that NTRK2 has mixed properties; it has shown expression patterns consistent with the inhibition of tumor progression in SCC lung cancer and cervical cancer, whereas in cutaneous and basal SCC, NTRK2 is enriched at sites of nerve invasion, and in vitro it can promote mesenchymal epithelial transition and chemotherapy resistance in head and neck cancer cell lines 41, 43, 52, 53. This evidence concerns the gene NTRK2 and lung cancer.