In the case of any of the investigated four polymorphisms (14094 insertion/deletion gene ACE, gene AGTR1 rs5186, rs1800469 gene TGFβ1 and GNB3 gene rs5443), there was no difference in the distribution of genotypes between patients with vesicoureteral reflux and the control group (Table 1) which indicates the absence of their relationship with the disease. The gene discussed is TGFB1; the disease is vesicoureteral reflux.