CYP3A5 and non-small cell lung carcinoma: In their 2008 paper, Kiyotani et al. [14] studied the effects of SNPs in seven genes potentially associated with transport and metabolism of docetaxel (CYP3A4, CYP3A5, ABCB1/MDR1, ABCC2/MRP2, SLCO1B3, NR1I2 and NR1I3) in Japanese patients with NSCLC.