Optimisation of blood transfusion was achieved by the use of cell saver, continuous availability of thromboelastometry (ROTEM, TEM Systems Inc.), protamine management, prevention of haemodilution, fibrinogen concentrates and prothrombin complex concentrates, intravenous administration of iron preoperatively in patients with iron deficiency anaemia, and careful haemostasis. Here, F2 is linked to Iron deficiency anemia.