INS and nicotine dependence: The significant pathways have a very heterogeneous spectrum in terms of functions as reported in KEGG database: hsa04725 is a Cholinergic synapse pathway, hsa04020 is a calcium signaling pathway, hsa04930 is a type 2 diabetes-related pathway, hsa04976 is a bile secretion pathway, hsa04728 is involved in dopaminergic synapses, has05033 is involved in nicotine addiction; hsa04911 is a insulin secretion pathway; and hsa04919 is a thyroid hormone signaling pathway.