VEGFA, which is secreted by MM cells and components of the BMM, promotes neo-angiogenesis, MM cells survival, migration, and has an immune-suppressive role.37 CCL3 is produced mainly by MM cells and acts as chemoattractant for monocyte-derived cells which, within the BMM, differentiate into macrophages or osteoclasts. Here, CCL3 is linked to Miyoshi myopathy.