Researchers found that HHcy might induce insulin resistance in adipose tissue by provoking endoplasmic reticulum (ER) stress, activating c-Jun N-terminal kinase (JNK) to promote proinflammatory cytokine production, facilitating macrophage infiltration, and promoting resistin expression and secretion from adipocytes [27,28]. This evidence concerns the gene MAPK8 and Insulin resistance.