For example, a number of studies have revealed a high frequency of inactivating mutations in ARID1A (a tumor suppressor gene involved in chromatin remodeling) in ovarian clear cell carcinomas [26,27], and amplification of ERBB2 (gene encoding for HER2) in 19% and 14% were reported in mucinous tumors and clear cell carcinomas of the ovary, respectively [22,37]. This evidence concerns the gene ERBB2 and ovarian clear cell cancer.