More specifically, serous tubal intraepithelial carcinomas (STICs), occurring within the fallopian tubes, are being closely scrutinized as possible precursor lesions of high-grade serous ovarian cancer [7,18,42], and the finding that TP53 mutations are common in these lesions, and may represent a very early driver mutation, provides support for this proposal [42,43]. Here, TP53 is linked to ovarian serous adenocarcinoma.