In this study of over 202,000 postmenopausal women aged 50 to 74 years, subjects were randomly assigned in a 1:1:2 ratio to ovarian cancer screening using a multimodal strategy (MMS) involving serum CA125 testing followed by transvaginal ultrasound as a second-line test in women with serum CA125 values exceeding a pre-established cutoff point, transvaginal ultrasound alone, or no screening [6]. Here, MUC16 is linked to ovarian cancer.