SOD1 and epilepsy: Since several studies have shown an increase in oxidative stress in epilepsy and have stated that free radicals can act as a pathogen in the disease [252,253], natural compounds with antioxidant properties were considered in preventing seizure-induced pathology [254,255]: results demonstrated that epilepsy could be partially prevented by treatment with antioxidants including SOD (Superoxide dismutase) mimetics, melatonin, vitamin C, and coenzyme Q10 [244].