In addition, autosomal dominant gain-of-function mutations in the PLCG2 gene cause PLCγ2-associated antibody deficiency and immune dysregulation (PLAID), also named “familial cold autoinflammatory syndrome 3” (FCAS3), clinically characterized by cold-induced urticaria, autoimmune manifestations, and susceptibility to infections. The gene discussed is PLCG2; the disease is PLCG2-associated antibody deficiency and immune dysregulation.