Multiple immune cells, such as macrophages, infiltrate into the tumor and adipose tissue microenvironments and cultivate a favorable environment for neoplastic cells due to alterations of the local cytokines profile, such as angiogenesis factors (i.e., epidermal growth factor (EGF)) and VEGF and inflammatory mediators (i.e., IL-6, TNF-α, leptin). Here, TNF is linked to neoplasm.