The role of hGDH2 in cancer is much less investigated than is that of hGDH1, although this isoenzyme was shown to promote growth of glioma cells possessing a mutation in the isocitrate dehydrogenase 1 (IDH1) gene, in a manner that is not mimicked by overexpression of hGDH1 [207]. Here, GLUD1 is linked to central nervous system cancer.