The search of enriched pathways showed that top 10 E2 interacting genes in AD: APOE, APP, ATP5A1, CALM1, CASP3, GSK3B, IL1B, MAPT, PSEN2 and TNF underlie the enrichment of the Kyoto Encyclopedia of Genes and Genomes (KEGG) Alzheimer’s disease pathway. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.