NRF1 and cancer: Table 4 showing enriched pathway analysis revealed the top pathways associated with the number of common E2, E2 and NRF1 target genes, that included: (1) Metabolism (49 genes); (2) Disease (48 genes); (3) Gene Expression (43 genes); (4) Immune System (36 genes); (5) Cell Cycle (35 genes); (6) Metabolic pathways (33 genes); (7) Signal Transduction (33 genes); (8) Metabolism of Proteins (28 genes); (9) Developmental Biology (25 genes); and (10) Cancer Pathways (22 genes).