NRF1 and Alzheimer disease: To validate findings from CTD curated data, we conducted Bayesian network (BN) analysis [271] of microarray data of 79 subjects of male (15 AD patients, 17 control) and female (17 AD patients, 30 controls) from Gene Expression Omnibus (GEO) database [272] showed that the female NRF1 gene network is completely different from male human AD patients (Figure 11).