NRF1 and neurodegenerative disease: Association of EED interacting genes common to both E2 and NRF1 targets with Neurodegenerative Diseases: Table 5 as well as Tables S1 and S2 summarize EEDs modified genes, which are common E2 and NRF1 target genes and their involvement with the specific type of brain disease, such as AD, PD, HD, ALS, Autism Spectrum Disorder, and Brain Neoplasms.