Enriched pathway analysis of E2/NRF1/DEHP-responsive genes revealed the top pathways for gene involvement that includes: (1) Metabolism (21 genes); (2) Metabolic pathways (15 genes); (3) Disease (15 genes); (4) Immune System (12 genes), (5) Metabolism of proteins (11 genes); (6) Cell Cycle (9 genes); (7) Cellular response to stress (8 genes); (8) Cancer Pathways (8 genes); (9) Developmental Biology (8 genes); and (10) Cell cycle (5 genes) (Table 4). Here, NRF1 is linked to cancer.