MAPT and Alzheimer disease: Therefore, perinatal BPA exposure might be a risk factor for the long-term neurodegenerative changes in offspring male mice [206].Phthalates have been demonstrated to induce nuclear transcription factors that are activators of telomerase reverse transcriptase (TERT), which has a role in tumor promotion [207], increase levels of phospho-tau, a precursor to AD [129], and affects dendritic spine density [120].