Bioinformatics analysis of gene-EEDs interactions and brain disease associations identified numerous NRF1 regulated genes that were altered by exposure to estrogen, phthalate or BPA or other EEDCs (APP, APLP1, MAPT, PEN2, PSEN2, PARH2, PINK1, PARK7, VDAC2, NR1 and 2b). The gene discussed is APP; the disease is brain disorder.