Creb3l3 deletion causes a defect in TG lipolysis in the blood, with Creb3l3−/− mice exhibiting hypertriglyceridaemia as a result of inefficient catalysis of TG clearance by lipoprotein lipase (LPL); this is due to a reduction in the expression of the LPL coactivators Apolipoprotein c2 (Apoc2), Apoa4, and Apoa5, and upregulation of the LPL inhibitor Apoc312, 13. This evidence concerns the gene APOC2 and hypertriglyceridemia.