ISL1 and amyotrophic lateral sclerosis: Moreover, we found five DEGs overlapping between our study and a gene expression study, even though it was performed in late-stage human ALS post-mortem spinal cord: PLP1, Protein kinase C zeta (PRKCZ), Cathepsin B (CTSB), Ankyrin G (ANK3) and Islet-1 (ISL1)26.