Notably, among the up-regulated genes annotated in these pathways Lamin A/C (LMNA) is required for normal development of skeletal muscle and PNS; moreover, mutations in the LMNA gene are associated with muscular dystrophy and hereditary peripheral neuropathy (Charcot-Marie-Tooth disease)14, 15. This evidence concerns the gene LMNA and Charcot-Marie-Tooth disease.