As previously seen in the case of regulating neuroblastoma cell (SK-N-MC) growth45, shortening the collagen-like repeat section around the cleavage site for MMPs-2, 7, -9, and -13 can be critical for the activity of Gal-3 on cells, likely by impairing self-association on a polyvalent surface. Here, LGALS3 is linked to neuroblastoma.