In the cases of Gal-1 and -3, the chimera-type protein is up to now viewed as antagonist of the negative growth regulator Gal-1 in neuroblastoma (SK-N-MC) and pancreas carcinoma (Capan-1) cells in vitro, in the latter case under the control of the p16INK4a tumour suppressor46, 47. This evidence concerns the gene CDKN2A and neuroblastoma.