Il8ra, Saa, Mmp8, Lcn2, Edn1, Ltf, Cp, Ccl2)15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 in C57/BL6J-βENaC-Tg mice were also reported to be increased at similar patterns with both COPD and CF lung tissues (Supplementary Tables 1,2). Here, EDN1 is linked to chronic obstructive pulmonary disease.