Our results, obtained in both ‘c-kit-dependent' and ‘c-kit-independent' MC-deficient mice thus strongly support the conclusion that even though TNFRSF14 can be expressed on multiple cell types, TNFRSF14 expression on MCs is necessary for the full development of multiple features of asthma pathology in our OVA model. The gene discussed is TNFRSF14; the disease is asthma.