ACE and ablepharon macrostomia syndrome: In this study, we conducted a cohort study to evaluate the effectiveness of the symptoms (including headache, insomnia, and anxiety), and the alterations in the levels of heart rate (HR), left ventricle (LV) Tei index, spirometric parameters, blood flow of the basilar artery (BA) and the vertebral artery (VA), mean arterial blood pressure (MABP), and angiotensin-converting enzyme (ACE) levels in AMS development.