As shown in Fig. 2d, only the expression of IL-6 (15.75±1.35 versus 7.192±2.20; p<0.01, ANOVA test) and TNF (10.80±2.86 versus 3.616±0.86; p<0.05, ANOVA test) was up regulated in the anti-IL-22 antibody-treated pancreatic islet-transplanted T1D mice. This evidence concerns the gene TNF and type 1 diabetes mellitus.