GALNT14 and central nervous system cancer: Among the 17 upregulated genes (Fig. 5a heat map and Supplementary Table 2), the progenitor transcription factor Sex-Determining Region Y-box4 (SOX4) caught our attention for the following reasons: (1) its expression exhibited the greatest fold-change upon both knockdown and overexpression of GALNT14; (2) SOX4 has been shown to be regulated by BMP signalling, which was identified as a target pathway of GALNT14 in the current study; and (3) increased SOX4 expression in glioma-initiating cells has been reported37.