In the search for novel targets that contribute to the pathogenesis of insulin resistance and type 2 diabetes, we recently described serine/threonine protein kinase 25 (STK25; also referred to as YSK1 or SOK1), a member of the sterile 20 (STE20) kinase superfamily [5], as a central regulator of ectopic lipid accumulation, and whole body glucose and insulin homeostasis [6–11]. The gene discussed is STK25; the disease is Insulin resistance.