SIRT3 and cancer: Previous reports have demonstrated that Sirt1 activates Akt and targets endothelial nitric oxide synthase in acute states of induced cardiac angiogenesis17 and that Sirt3 destabilizes hypoxia‐inducible factor‐1α to reduce transcription of the proangiogenic gene vascular endothelial growth factor‐A (VEGF‐A) in cancer cell lines during hypoxia;18 however, there are no studies reporting the role of Sirt3 in cardiac angiogenesis.