Recently, it was reported that the anticancer drug DNR and potential MDR modulator 5‐bromotetrandrine (5‐BrTet) co‐loaded with iron oxide nanoparticles could increase the accumulation of loaded compounds (5‐BrTet and DNR) and downregulate the expression of mdr‐1 gene, ultimately resulting in significant therapeutic effects in MDR cancer cells.79 Here, ABCB1 is linked to cancer.