PGP and cancer: For instance, the DOX‐loaded‐poly(lactic‐co‐glycolic acid) hybrid gold nanoparticles functionalized with targeting moieties of anti‐death receptor‐4 monoclonal antibody (Figure5A,B) were employed to treat MDR cancers by chemo‐photothermal therapy.108 These nanoparticles could increase the amount of drugs delivered to tumors and decrease the activity of P‐gp by heat generated from Au nanoparticles after laser irradiation.