There are numerous studies applying gold nanoparticles for cancer PTT in preclinical and clinical trials.105, 106 It was reported that anti‐HER2+ coated silica/gold nanoshells could selectively bind to MDR HER2+ breast cancer cells to overcome drug resistance and kill cancer cells with PTT.107 Moreover, by combining PTT with chemotherapy, it could induce synergistic effects and eliminate MDR cancer cells more effectively. The gene discussed is ERBB2; the disease is breast cancer.