In another study, the reverse of MDR by MSN was also achieved by reducing the P‐gp expression and effective cell internalization.133 Furthermore, by modifying with TAT peptides on the surface of MSNs, they can deliver DOX directly into the nucleus and induce apoptosis of MDR MCF‐7/ADR cancer cells.134 Additionally, by co‐loading two anticancer drugs into MSNs could ultimately reverse the MDR in resistant cancer cells. The gene discussed is PGP; the disease is cancer.