CASP3 and heart failure: That finding, as well as the marked caspase-3 expression in the control group, changes in nuclei structure in heart failure, alterations in transcription noted by other authors [26], and the negative correlation between caspase-3 expression and cardiomyocyte degeneration, all suggest that the transcription of caspase-3 may be altered in DCM patients, thus leading to the use of all the available cytoplasmic caspase-3.