We therefore decided to use two different controls of normal B cells: first, the peripheral normal B cell from healthy donors since they represent intuitively the normal counterpart in the healthy donors; second, the B cells from the umbilical cord blood since they express the CD5 similarly to CLL [40] and because Saunders et al. demonstrated that they display a similar proteic profile to CLL [41]. This evidence concerns the gene CD5 and B-cell chronic lymphocytic leukemia.