These 11 SNP-CpG pairs were composed of 5 unique SNPs (rs13203895 in USP8P1, rs2853953 in HLA-C, rs10484554 nearby WASF5P, rs2245822 nearby HLA-C, and rs2853952 in HLA-C) and 3 CpG sites (cg04087571 in SIK3, cg09914444 in DMBX1, and cg0683507 in C1orf106) and presented a methylation-mediated relationship between SNPs and psoriasis. This evidence concerns the gene HLA-C and psoriasis.