In T2D patients, TLR8 gene expression correlated with TNF-α (r = 0.31, P = 0.04) (Fig. 5e), IL-18 (r = 0.53, P = 0.0001) (Fig. 5f), and IL-8 (r = 0.47, P = 0.001) (Fig. 5g); whereas, no correlation was found with plasma CRP levels (r = −0.04, P = 0.81) (Fig. 5h). Here, TNF is linked to type 2 diabetes mellitus.