The innate immune TLRs have potential to play direct or indirect roles in obesity- or T2D-associated metabolic inflammation and, therefore, we asked whether the adipose tissue TLR8 gene expression was linked with the expression of other immunometabolic TLRs such as TR2 and TLR4 as well as with downstream MyD88 adapter protein. This evidence concerns the gene TLR8 and type 2 diabetes mellitus.