Since the TLR8 stimulation was linked to induction of proinflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-12) in peripheral blood mononuclear cells (PBMC), dendritic cells (DCs), and monocytes [16] as well as related with anti-inflammatory IL-10 production [17], we wanted to know if the TLR8 expression was modulated in metabolic disease as has been observed for surface TLRs especially, TLR2 and TLR4. The gene discussed is TLR8; the disease is metabolic disease.