CCL2 and obesity due to melanocortin 4 receptor deficiency: We found that the adipose tissue expression of these markers was associated with corpulence phenotype i.e. BMI which meant that obesity could be a positive modulator of monocyte/macrophage influx into the adipose tissue which is known to secrete chemotactic adipokines including CC-chemokine ligand (CCL)-2 or macrophage chemoattractant protein (MCP)-1 as shown earlier by a diet-induced obesity study in mice [21].