Additionally, analysis of the within-group associations of TLR8 gene expression with other inflammatory markers in the adipose tissue indicates that obesity- and T2D-associated inflammatory changes including macrophage infiltration, upregulated expression of proinflammatory cytokines/chemokines, increased surface TLRs (TLR2/4) and downstream adapter protein MyD88 may be linked, at different levels, to the induction/upregulation of TLR8 in the adipose tissue. Here, MYD88 is linked to obesity due to melanocortin 4 receptor deficiency.