Our data further show an association between these inflammatory adipokines and TLR8 expression in the adipose tissue; however, CRP levels in T2D individuals did not correlate with TLR8 gene expression and we speculate that this discrepancy may be due to T2D-associated comorbid factors such as liver dysfunction, central adiposity, hyperglycemia, and insulin resistance. Here, TLR8 is linked to Insulin resistance.