IGF1 and injury: EP therapy (a single dose of EP at 25 mg/kg was intraperitoneally injected 30 min after HI brain injury, and brain samples were harvested at 3 h, 6 h, 12 h, 24 h,48 h,72 h, 7 days and 4 weeks after HI brain injury) and the insulin-like growth factor-1 (IGF-1) treatment protect the neonatal rats brain against HI injury and improve neurological performance and these effects are additive [84].