NFKB1 and colitis: EP does not inhibit nuclear translocation of NF-kB family members but attenuates NF-kB DNA binding in an experimental colitis model [95], more specifically, EP inhibits NF-kB activation by alkylating a critical cysteine residue (Cys38) in the p65 subunit of the NF-kB heterodimer, and alkylation of Cys38 interferes with DNA-binding by the transcription factor [1, 2].