In addition, through the above-mentioned bioinformatics analyses, 4 genes (RSPO3, ADAMTS8, DMBT1, and DOCK8) and 3 pathways (PI3K-Akt signaling pathway, TGF-beta signaling pathway and Hippo signaling pathway) were identified as related to NSCLC. This evidence concerns the gene RSPO3 and non-small cell lung carcinoma.