And the ROC curve revealed that the area under curve (AUC) of HOXA11-AS was 0.727 (95% CI 0.663–0.790) for lung adenocarcinoma patients and 0.933 (95% CI 0.906–0.960) for squamous cell carcinoma patients (both P < 0.0001), which could gain high diagnostic value of HOXA11-AS level in NSCLC (Fig. 10c, d). This evidence concerns the gene HOXA11 and lung adenocarcinoma.