PVT1 and neoplasm: For example, lncRNA-TATDN1 is associated with NSCLC invasion and metastasis by influencing E-cadherin, HER2, β-catenin and Ezrin expression [12], lncRNA-PVT1 promotes NSCLC cell proliferation by epigenetically regulating LATS2 expression [13] and lncRNA-MALAT1 influences tumor invasion in NSCLC by regulating DNA methylation [14].