In childhood pre-B ALL, two studies showed that expression of lncRNAs correlated with cytogenetic abnormalities, disease subtypes, and survival of B-ALL patients.[21] (Lajoie et al. submitted) The B-ALL-associated long RNA-2 (BALR-2) has been shown to be specifically upregulated in MLL-rearranged ALL.[21] BALR-2 was identified as a modulator of the response to GC treatment.[21]. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.