CHL1 and cancer: HOTAIR is deregulated in a spectrum of cancers, and its overexpression is associated with poor prognosis in breast, [16] liver, [17] colorectal, [18] gastrointestinal, [19] and pancreatic [20] cancers, and is proposed to increase tumor invasiveness and metastasis.[16] Recent expression studies performed on pre-B cALL samples have shown that lncRNA expression profiles can accurately classify disease subtypes and are correlated with outcome, [3, 21] (Lajoie et al., submitted).