NOTCH1 and hematologic disorder: Perturbation of NOTCH1 signaling has been shown in different solid tumors such as lung [29], breast [30], liver [31], gastric [32] and prostate [33] carcinomas and hematologic malignancies such as lymphomas, T-ALLs and CLLs [34], where it is associated with EMT and cancer stem cells self-renewal and preservation [35, 36].