As shown in Figure 3B, AML cell apoptosis was significantly higher when ATP and ARA-C were combined as compared to their use as single compound (% of Annexin-V+ cells: 4 μM ARA-C+ ATP 78.7 ± 5.3% vs ATP 58.6 ± 5.3% and ARA-C 59.5 ± 5.4%, p < 0.05). The gene discussed is ANXA5; the disease is acute myeloid leukemia.