This observation is supported by evidence from The Cancer Genome Atlas (TCGA), which revealed while PTEN was mutated or altered in only ~2% of lung adenocarcinoma cases (Supplementary Figure S4A), PTEN mRNA levels were significantly lower in 517 cases of lung adenocarcinomas as compared to normal lung tissues (Supplementary Figure S4B). The gene discussed is PTEN; the disease is lung adenocarcinoma.