Recently, Wang et al. [29] identified the zinc finger protein ZRANB2 as a novel maternal LPS-binding protein that protects embryos of zebrafish against Gram-negative bacterial infections and they also found rZRANB2 can bind to lipid A, a core component of LPS, and the affinity of rZRANB2 to LPS was not inhibited by any of the sugars examined. Here, ZRANB2 is linked to gram-negative bacterial infections.