The RR (RR = 2.163, 95% CI: 1.092–4.287, Fig. 3) was higher than one and the p was lower than 0.05 (p = 0.027), indicating that the low IGFBP-3 level was associated with low 3-year survival rate, and for esophageal cancer patients, the 3-year survival rate of patients with low IGFBP-3 level was lower than that in patients with relatively high IGFBP-3 level. The gene discussed is IGFBP3; the disease is esophageal cancer.