For patients in N category, the OR was 3.211 (95% CI: 1.561–6.607, p = 0.002, Fig. 4), indicating that the IGFBP-3 level in patients of N category whose tumor cells had lymph node metastasis were significantly lower than that in patients without lymph nodes in tumor cells. This evidence concerns the gene IGFBP3 and neoplasm.