Our findings were consistent with the studies by Miller et al. and Ebersole et al. who also reported a significantly higher mean level of saliva IL-1β, IL-6 in the saliva and IL-1β and TNF-α in serum of people with periodontal disease [7, 29, 30], but our findings differ from the research conducted by Teles et al. and de Queiroz et al. [31, 32], who did not find a statistically significant differences of inflammatory mediators in saliva or in serum between people with periodontal disease and without periodontal disease. Here, IL6 is linked to periodontal disorder.