GSK3B and melanoma: We utilized a well‐characterized GSK3β inhibitor, Bromoindirubin‐3′‐oxime (subsequently referred to as BIO), that has been used to investigate the effects of increased Wnt signaling in many model systems, including mammalian cardiomyocyte cell culture, melanoma cells (B16‐F0), normal human melanocyte (NHM) cells, mouse embryonic stem cells, and zebrafish (Alexander et al., 2014; Bellei et al., 2008, 2010; Kim et al., 2010; Moro et al., 2012; Sineva and Pospelov, 2010; Tseng et al., 2006).