AFP-L3 is synthesized by α1,6-fucosyltransferase (fucosyltransferase 8, FUT8), the only enzyme responsible for α1,6-linked fucosylation involving the addition of fucose to the innermost GlcNAc residue of an N-linked glycan.[8] FUT8 is overexpressed in several malignancies including lung,[9] colorectal cancers,[10] and HCC.[11,12] Notably, FUT8 levels increase in plasma and liver tissues with progression of hepatocarcinogenesis. This evidence concerns the gene FUT8 and colorectal cancer.