We previously reported that HDACis, such as sodium butyrate and tricostatin A, enhanced p53 function by lysine acetylation, thereby inducing PIG3 and NOXA, which are pro-apoptotic molecules.[16] Therefore, we used SAHA, a HDACi, to augment FUT8 expression in HCC cell lines. This evidence concerns the gene PMAIP1 and hepatocellular carcinoma.