The tumor suppressor, p53, is the most commonly mutated gene in human tumors; mutated -p53 facilitates increased proliferation, survival and metastatic potential.[14] Mutations of p53 have been found in approximately 25% of HCC patients.[15] Growing evidence has implicated the p53 pathway in hepatocarcinogenesis and the progression of HCC. This evidence concerns the gene TP53 and hepatocellular carcinoma.